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Tuesday, April 2, 2013
The Doctor?s World: Link to Ethical Scandals Tarnishes Prestigious Parran Award
[unable to retrieve full-text content]A debate is raging around a prize named after Dr. Thomas Parran Jr., who has been linked to unethical experiments, including the Tuskegee syphilis study.
Maroon 5 Have 'Great Songs' Recorded For Next Album
'We're just getting started,' singer Adam Levine says of the follow-up to Overexposed.
By Gil Kaufman
Maroon 5
Photo: Daniel Boczarski/Getty Images
Source: http://www.mtv.com/news/articles/1704674/maroon-5-overexposed-album.jhtml
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Monday, April 1, 2013
Egyptian TV satirist appears before prosecutors
CAIRO (AP) ? A popular television satirist known as Egypt's Jon Stewart was released on bail Sunday after nearly five hours of interrogation over allegations that he broke the law by insulting Islam and the country's leader.
Bassem Youssef is the most prominent critic of Islamist President Mohammed Morsi to be called in for questioning in recent weeks in what the opposition says is a campaign to intimidate critics. Arrest warrants have been issued for five prominent anti-government activists accused of instigating violence.
A prosecution official said Youssef was to pay a bail of 15,000 LE ($2,200), pending the completion of an investigation.
Youssef tweeted that the bail is for three separate cases. The date for an expected fourth interrogation has not been set, he added.
Rights lawyer Gamal Eid said the release on bail means "all options are open."
"The prosecution could continue investigation, put the case aside or send it to trial," Eid said.
Youssef, the host of the weekly show "ElBernameg," or "The Program," is known for his skits lampooning Morsi and Egypt's newly empowered Islamist political class, but he also mocks the opposition and the media.
Several dozen supporters gathered outside the public prosecutor's office as he presented himself for questioning a day after a warrant for his arrest was first reported in the media.
The media also intently followed the comedian's interrogation. He first tweeted a series of quips from the prosecutor's office. "They asked me the color of my eyes. Really," one read.
A news broadcaster at a TV station affiliated with Morsi's Muslim Brotherhood group, Misr 25, said he was "mocking" the investigation, and his tweets later were erased and he wrote that some reports from inside the interrogation room were "incorrect."
The fast-paced show has attracted a wide viewership, while at the same time earning itself its fair share of detractors. Youssef has been a frequent target of lawsuits, most of them brought by Islamist lawyers who have accused him of "corrupting morals" or violating "religious principles."
Prosecutor Mohammed el-Sayed Khalifa was quoted on the website of the state-owned Al-Ahram daily that he has heard 28 plaintiffs accusing Youssef of insulting Islam, mocking prayers, and "belittling" Morsi in the eyes of the world and his own people.
Youssef frequently imitates Morsi's speeches and gestures. He has fact-checked the president, and in one particularly popular episode earlier this year, Youssef played video clips showing remarks by Morsi, made in 2010 before he became president, where the Muslim Brotherhood veteran called Zionists "pigs."
The remarks caused a brief diplomatic tiff with the U.S. administration, and Morsi had to issue a statement to defuse the flap.
In his last episode this week, Youssef thanked Morsi for providing him with so much material.
Youssef has also made regular jokes about comments by Islamic clerics and Islamic stations TV presenters, exposing contradictions between their comments and public speeches and what he considers the spirit of Islam.
In remarks to a TV presenter on CBC, the private station that airs his Friday program, Youssef said late Saturday that his program does not insult Islam but aims to expose those who "distort" it.
"We don't insult religion. What we do is expose those so-called religious and Islamic stations which have offended Islam more than anyone else," he said. "If anyone is to be investigated for insulting religions, it should be all those who use Islam as a weapon and a political tool to swallow the others using religion."
When asked if programs in Egypt should be less scathing than those of the West, Youssef jibed: "We will give (the West) an example of how freedoms are respected after the revolution," referring to Egypt's 2011 uprising that overthrew authoritarian leader Hosni Mubarak.
Amr Moussa, a former presidential candidate and Arab League secretary general, called the warrant a "provocation to Egyptians who are known for their love of what is funny," he said.
"There is nothing odious about criticizing the president," he said in an emailed statement. "This humanizes the president."
Eid, the rights lawyer, said accusing Youssef of insulting religion ? as opposed to just the president ? is a tactic aimed at increasing public sympathy for the investigation.
"The accusation of insulting religion would mobilize more people against him," Eid said.
The release on bail means "all options are open," Eid added. "The prosecution could continue investigation, put the case aside or send it to trial."
Recent legal moves against protesters, activists and critics come as unrest in Egypt continues amid deep political polarization.
The opposition charges that Morsi, in office for nine months, has failed to tackle any of the nation's most pressing problems. They say the Brotherhood is trying to monopolize power, breaking its promises to include other factions in key decisions.
Morsi blames the country's woes on corruption under Mubarak as well as ongoing protests. He says the opposition has no grassroots support and, along with former regime supporters, is stoking unrest for political gain.
Source: http://news.yahoo.com/egyptian-tv-satirist-appears-prosecutors-101256553.html
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Sorting out Parkinson's protein structure: Computer modeling may offer hints for new drug-design strategies
Apr. 1, 2013 ? Clumps of proteins that accumulate in brain cells are a hallmark of neurological diseases such as dementia, Parkinson's disease and Alzheimer's disease. Over the past several years, there has been much controversy over the structure of one of those proteins, known as alpha synuclein.
MIT computational scientists have now modeled the structure of that protein, most commonly associated with Parkinson's, and found that it can take on either of two proposed states -- floppy or rigid. The findings suggest that forcing the protein to switch to the rigid structure, which does not aggregate, could offer a new way to treat Parkinson's, says Collin Stultz, an associate professor of electrical engineering and computer science at MIT.
"If alpha synuclein can really adopt this ordered structure that does not aggregate, you could imagine a drug-design strategy that stabilizes these ordered structures to prevent them from aggregating," says Stultz, who is the senior author of a paper describing the findings in a recent issue of the Journal of the American Chemical Society.
For decades, scientists have believed that alpha synuclein, which forms clumps known as Lewy bodies in brain cells and other neurons, is inherently disordered and floppy. However, in 2011 Harvard University neurologist Dennis Selkoe and colleagues reported that after carefully extracting alpha synuclein from cells, they found it to have a very well-defined, folded structure.
That surprising finding set off a scientific controversy. Some tried and failed to replicate the finding, but scientists at Brandeis University, led by Thomas Pochapsky and Gregory Petsko, also found folded (or ordered) structures in the alpha synuclein protein.
Stultz and his group decided to jump into the fray, working with Pochapsky's lab, and developed a computer-modeling approach to predict what kind of structures the protein might take. Working with the structural data obtained by the Brandeis researchers, Stultz created a model that calculates the probabilities of many different possible structures, to determine what set of structures would best explain the experimental data.
The calculations suggest that the protein can rapidly switch among many different conformations. At any given time, about 70 percent of individual proteins will be in one of the many possible disordered states, which exist as single molecules of the alpha synuclein protein. When three or four of the proteins join together, they can assume a mix of possible rigid structures, including helices and beta strands (protein chains that can link together to form sheets).
"On the one hand, the people who say it's disordered are right, because a majority of the protein is disordered," Stultz says. "And the people who would say that it's ordered are not wrong; it's just a very small fraction of the protein that is ordered."
"This paper seems to bridge the gap" between the two camps, says Trevor Creamer, an associate professor of molecular and cellular biochemistry at the University of Kentucky who was not involved in this research. Also important is the model's prediction of new structures for the protein that experimental biologists can now look for, Creamer adds.
The MIT researchers also found that when alpha synuclein adopts an ordered structure, similar to that described by Selkoe and co-workers, the portions of the protein that tend to aggregate with other molecules are buried deep within the structure, explaining why those ordered forms do not clump together.
Stultz is now working to figure out what controls the protein's configuration. There is some evidence that other molecules in the cell can modify alpha synuclein, forcing it to assume one conformation or another.
"If this structure really does exist, we have a new way now of potentially designing drugs that will prevent aggregation of alpha synuclein," he says.
Lead author of the paper is Thomas Gurry, an MIT graduate student in computational and systems biology. Other authors are Orly Ullman, an MIT graduate student in chemistry; Pochapsky, a professor of chemistry and biochemistry at Brandeis; Iva Perovic, a graduate student in Pochapsky's lab; and Charles Fisher, a Harvard graduate student in biophysics.
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The above story is reprinted from materials provided by Massachusetts Institute of Technology. The original article was written by Anne Trafton.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
- Thomas Gurry, Orly Ullman, Charles K. Fisher, Iva Perovic, Thomas Pochapsky, Collin M. Stultz. The Dynamic Structure of ?-Synuclein Multimers. Journal of the American Chemical Society, 2013; 135 (10): 3865 DOI: 10.1021/ja310518p
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/kvkaYuWaeuo/130401111638.htm
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'True Blood' announces season 6 return date
By Jolie Lash , Access Hollywood
?Truebies? can start the countdown to Season 6 of ?True Blood.??On Friday, HBO revealed that the show will premiere on June 16 at 9 p.m. on the cable network.
VIEW THE PHOTOS: "Game Of Thrones" Season 3 premiere & after-party
There will be 10 episodes this season.
VIEW THE PHOTOS: An evening with the cast of "Game Of Thrones"
Shooting has already begun on the show, based on the books by Charlaine Harris, and created for television by Alan Ball.
?It?s crazy. I can?t believe we?ve gotten this far,? Janina Gavankar, who plays shapeshifter Luna, told Access Hollywood at the premiere of another HBO show -- ?Game of Thrones? -- last week in Los Angeles.
VIEW THE PHOTOS: "Game Of Thrones": Season 3 poster art
?We sat down at that first table read and it was like, ?Season 6, what the heck!?? she continued. ?But I mean, it?s a well-oiled machine and it?s crazier than ever.?
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